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6. Traits whose genes increase ADHD risk

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6. Traits whose genes increase ADHD risk

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A large-scale genetic study found several complex traits whose genetic causes put people at higher risk for ADHD:1

GCP : Genetical causal proportion.
Negative values mean that the trait is a causal risk for ADHD (the lower the negative value, the stronger). Positive values mean that the trait is a causal consequence of ADHD (the higher the positive value, the stronger).

Trait (characteristic) GCP (here: negative) genetic causal relationship with ADHD
At least one person recommended reducing alcohol consumption - 0.96
Iron deficiency anemia (ICD10) - 0.94
Synovitis and tenosynovitis (ICD10) - 0.94
Entropion (malposition) or trichiasis (eyelashes directed towards the eyeball) of the eyelid - 0.94
Peripheral artery disease - 0.87
Other disorders of fluid, electrolyte and acid-base balance (ICD10) - 0.85
Assisted Living - 0.85
Restriction of smoking due to illness - 0.82
Neck or shoulder pain for more than 3 months - 0.82
Diseases of the synovium (inner joint capsule mucosa) or tendons - 0.82
Self-reported type 2 diabetes - 0.81
Medication: Enalapril (medication for high blood pressure) - 0.76
Medication: Felodipine (high blood pressure medication) - 0.77
Self-reported COPD + 0.75
Other osteoarthritis (ICD10) - 0.74
Syncope and collapse (ICD10) - 0.74
Disabled person’s card (Blue Badge) + 0.73
Obesity - 0.73
Work in shifts - 0.73
Mania or irritability manifestations: easily distracted - 0.72
Drug: gabapentin (anti-epileptic) - 0.71
Drug: Pantoprazole - 0.70
Other diseases of the anus and rectum (ICD10) - 0.69
Polyarthrosis (ICD10) - 0.69
Carpal tunnel syndrome + 0.68
Fibroblastic diseases - 0.67
Incapacity to work due to illness or disability - 0.67
Diseases of the skin and subcutaneous tissue - 0.67

  1. García-Marín, Campos, Cuéllar-Partida, Medland, Kollins, Rentería (2021): Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD. Sci Rep. 2021 Nov 19;11(1):22628. doi: 10.1038/s41598-021-01517-7. PMID: 34799595; PMCID: PMC8604995. ↥

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