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ADHD treatment reduces comorbidities

ADHD treatment reduces comorbidities

In addition to reducing ADHD symptoms, treatment of ADHD also reduces symptoms of comorbid stress in many areas.

1. Normalization of comorbid mental disorders through ADHD medication

The symptoms in these areas, which were clearly comorbidly elevated before treatment, are returned to normal ranges within 4 to 6 months of methylphenidate treatment.123 This description is consistent with our experience, although we do not believe that these are merely subjective improvements due to therapeutic expectations, but rather we consider this to be a direct therapeutic effect.4

ADHD treatment brings about improvements in terms of

  • Compulsiveness (sharp decline)5
  • Depressiveness16
  • Anxiety7
  • Phobic anxiety7
  • Aggressiveness73
  • Social introversion (here: indicated shyness, introversion, etc.) - strong decline, insecurity in social contact, social inhibition783
  • Social orientation3
  • Excitability3
  • Hypomania6
  • General life satisfaction (here: positive basic mood, confidence, etc.)3
  • Feeling of strain (tense, overwhelmed, stressed)3
  • Emotionality3
  • Extraversion3
  • Openness3
  • Somatization5
  • Physical complaints (less significant decrease)3
  • Paranoid thinking5
  • Psychoticism (here: feelings of isolation, distorted experience, etc.)5
  • Hypochondria6
  • Hysteria (conversion disorder)6
  • Paranoia6
  • Psychasthenia (neuroses)6
  • Schizophrenia (here: strange ideas, unusual feelings, etc.) - sharp decline6

There were deteriorations in the following areas

  • Performance orientation3
  • Health worries (even if only minor)3

Psychopathy remained unchanged.6

After 4 to 6 months of methylphenidate therapy, the diagnostic criteria for ADHD were no longer met in over 80% of the test subjects.9

2. Normalization of symptoms of the Personality Style and Disorder Inventory (PSSI) through ADHD medication

ADHD sufferers develop all 14 personality areas of the PSSI positively during methylphenidate therapy, i.e. away from the pole of a possible personality disorder of the trait and towards the area of normal personality characteristics.10 This description is in line with our experience, although we do not believe that these are merely subjective improvements based on therapeutic expectations,4 but rather we consider this to be a direct therapeutic effect.

  • Headstrong - paranoid11
  • Reserved - schizoid11
  • Clueless - schizotypal11
  • Spontaneous - borderline11
  • Amiable - histrionic11
  • Ambitious - narcissistic11
  • Self-critical - self-confident11
  • Loyal - dependent11
  • Carefully - compulsively11
  • Critical - negativistic11
  • Silent - depressive11
  • Helpful - selfless11
  • Optimistic - rhapsodic11
  • Self-assertive - antisocial11

At the start of the test, the symptoms were already below the threshold at which a personality disorder would have been considered. However, the positive development documents the development towards more balanced personality traits. These are of great subjective benefit to those affected.


  1. Edel, Vollmoeller: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung bei Erwachsenen, 2006, S. 91 ff, Symptome nach Symptom-Checkliste SCL-90-R, Derogatis, 1977 / Franke, 1995. Achtung, geringe Probandenzahl von n = 22

  2. Edel, Vollmoeller: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung bei Erwachsenen, 2006, S. 93 ff, Symptome nach Minnesota Multiphasic Personality Inventory (MMPI-2), Engel, 2000. Achtung, geringe Probandenzahl von n = 22

  3. Edel, Vollmoeller: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung bei Erwachsenen, 2006, S. 94 ff, Symptome nach Freiburger Persönlichkeitsinventar FPI-R, 1984. Achtung, geringe Probandenzahl von n = 22

  4. Edel, Vollmoeller: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung bei Erwachsenen, 2006, Seite 100

  5. Edel, Vollmoeller: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung bei Erwachsenen, 2006, S. 91 ff, Symptome nach Symptom-Checkliste SCL-90-R (Derogatis, 1977 / Franke, 1995). Achtung, geringe Probandenzahl von n = 22.

  6. Edel, Vollmoeller: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung bei Erwachsenen, 2006, S. 93 ff, Symptome nach Minnesota Multiphasic Personality Inventory (MMPI-2) (Engel, 2000). Achtung, geringe Probandenzahl von n = 22

  7. Edel, Vollmoeller: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung bei Erwachsenen, 2006, S. 91 ff, Symptome nach Symptom-Checkliste SCL-90-R, Derogatis, 1977 / Franke, 1995. Achtung, geringe Probandenzahl von n = 22.

  8. Edel, Vollmoeller: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung bei Erwachsenen, 2006, S. 93 ff, Symptome nach Minnesota Multiphasic Personality Inventory (MMPI-2). Engel, 2000. Achtung, geringe Probandenzahl von n = 22

  9. Edel, Vollmoeller: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung bei Erwachsenen, 2006, Seite 99 – 18 von 22 Patienten = 81,8%, 31,8% ist wohl ein Schreibfehler.

  10. Edel, Vollmoeller: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung bei Erwachsenen, 2006, Seite 97 ff

  11. Edel, Vollmoeller: Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung bei Erwachsenen, 2006, S. 97 ff, Symptome nach Persönlichkeits-Stil- und Störungsinventar (PSSI). Achtung, geringe Probandenzahl von n = 22

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