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Locus coeruleus

Locus coeruleus

The locus coeruleus regulates attention and is an important mediator of stress responses.
It is activated by orexin and sends the norepinephrine it produces to quite a few brain regions involved in stress systems.

  • Stimulated by orexin
  • Afferents (received signals) from:
    • MPFC
      • Constant stimulating input according to the activity level
    • Nucleus paragigantocellularis
      • Integrates autonomous and environmental stimuli
    • Nucleus prepositus perihypoglossalis
      • Controls horizontal and vertical eye movements, gaze following movements and gaze fixation
    • Lateral hypothalamus
      • Produces orexin
  • Produces noradrenaline
  • Efferences (sends signals) to:
    • Amygdala
    • Hippocampus
    • Brainstem
    • Spinal cord
    • Cerebellum
    • Cortex
    • Hypothalamus
    • Tectum (dorsal mesencephalon)
    • Thalamus
    • Ventral tegmentum

Chronic activation of the locus coeruleus appears to reduce the stress response1

Chemical deactivation of the locus coeruleus acutely and briefly reduced the HPA axis response. However, after 4 weeks of chronic stress, the HPA axis response was fully restored despite deactivated LC.2 This suggests that the primarily appears to mediate acute stress responses.

Diese Seite wurde am 13.03.2023 zuletzt aktualisiert.