Dear readers of ADxS.org, please forgive the disruption.

ADxS.org needs about $36850 in 2023. In 2022 we received donations from third parties of about $ 13870. Unfortunately, 99.8% of our readers do not donate. If everyone who reads this request makes a small contribution, our fundraising campaign for 2023 would be over after a few days. This donation request is displayed 18,000 times a week, but only 40 people donate. If you find ADxS.org useful, please take a minute and support ADxS.org with your donation. Thank you!

Since 01.06.2021 ADxS.org is supported by the non-profit ADxS e.V..

$16307 of $36850 - as of 2023-08-31
44%
I would like to donate via PayPal
More info about donations
ADxS.org Logo
ADxS.org Logo
Search Sitemap Donations Last Changes Deutsche Version
Register

Existing Account? Login

Header Image
Locus coeruleus

Sitemap

The ADxS.org project
Abstract of ADxS.org
Symptoms
Consequences
Origin
Stress
Neurological aspects
Diagnostics
Prevention
Treatment and therapy
This and That about ADHD
Tests and surveys
Forum

Locus coeruleus

Previous Page Next Page

The locus coeruleus regulates attention and is an important mediator of stress responses.
It is activated by orexin and sends the norepinephrine it produces to quite a few brain regions involved in stress systems.

  • Stimulated by orexin
  • Afferents (received signals) from:
    • MPFC
      • Constant stimulating input according to the activity level
    • Nucleus paragigantocellularis
      • Integrates autonomous and environmental stimuli
    • Nucleus prepositus perihypoglossalis
      • Controls horizontal and vertical eye movements, gaze following movements and gaze fixation
    • Lateral hypothalamus
      • Produces orexin
  • Produces noradrenaline
  • Efferences (sends signals) to:
    • Amygdala
    • Hippocampus
    • Brainstem
    • Spinal cord
    • Cerebellum
    • Cortex
    • Hypothalamus
    • Tectum (dorsal mesencephalon)
    • Thalamus
    • Ventral tegmentum

Chronic activation of the locus coeruleus appears to reduce the stress response1

Chemical deactivation of the locus coeruleus acutely and briefly reduced the HPA axis response. However, after 4 weeks of chronic stress, the HPA axis response was fully restored despite deactivated LC.2 This suggests that the primarily appears to mediate acute stress responses.

  1. Velley, Cardo, Kempf, Mormede, Nassif-Caudarella, Velly (1991): Facilitation of learning consecutive to electrical stimulation of the locus coeruleus: cognitive alteration or stress-reduction?. Prog Brain Res. 1991;88:555-569. doi:10.1016/s0079-6123(08)63834-0 ↥

  2. Ziegler DR, Cass WA, Herman JP. Excitatory influence of the locus coeruleus in hypothalamic-pituitary-adrenocortical axis responses to stress. J Neuroendocrinol. 1999;11(5):361-369. doi:10.1046/j.1365-2826.1999.00337.x ↥

Diese Seite wurde am 13.03.2023 zuletzt aktualisiert.
Previous Page Next Page