Dear readers of ADxS.org, please forgive the disruption.

ADxS.org needs about $19740 in 2023. In 2022 we received donations from third parties of about $ 13870. Unfortunately, 99.8% of our readers do not donate. If everyone who reads this request makes a small contribution, our fundraising campaign for 2023 would be over after a few days. This donation request is displayed 12,000 times a week, but only 140 people donate. If you find ADxS.org useful, please take a minute and support ADxS.org with your donation. Thank you!

Since 01.06.2021 ADxS.org is supported by the non-profit ADxS e.V..

$0 of $19740 - as of 2023-01-03
0%
Header Image
Locus coeruleus

Locus coeruleus

The locus coeruleus regulates attention and is an important mediator of stress responses.
It is activated by orexin and sends the norepinephrine it produces to quite a few brain regions involved in stress systems.

  • Stimulated by orexin
  • Afferents (received signals) from
    • MPFC
      • Constant stimulating input according to the activity level
    • Nucleus paragigantocellularis
      • Integrates autonomous and environmental stimuli
    • Nucleus prepositus perihypoglossalis
      • Controls horizontal and vertical eye movements, gaze following movements and gaze fixation
    • Lateral hypothalamus
      • Produces orexin
  • Produces noradrenaline
  • Efferences (sends signals) to
    • Amygdala
    • Hippocampus
    • Brainstem
    • Spinal cord
    • Cerebellum
    • Cortex
    • Hypothalamus
    • Tectum (dorsal mesencephalon)
    • Thalamus
    • Ventral tegmentum

Chronic activation of the locus coeruleus appears to reduce the stress response1

Chemical deactivation of the locus coeruleus acutely and briefly reduced the HPA axis response. However, after 4 weeks of chronic stress, the HPA axis response was fully restored despite deactivated LC.2 This suggests that the primarily appears to mediate acute stress responses.

Diese Seite wurde am 08.08.2022 zuletzt aktualisiert.