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Acetylcholine regulates

  • Memory formation1

Acetylcholine has a very similar structure to nicotine and binds to the same receptors. The high comorbidity of ADHD and smoking indicates a connection.2

The importance of acetylcholine in relation to ADHD has remained largely unexplored.

A meta-analysis study reported increased choline levels in ADHD sufferers in the3

  • PFC
  • Striatum
  • Anterior cingulate cortex.

Choline is a precursor of acetylcholine as well as phosphatidyl choline and sphingomyelin.