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Frustration intolerance in ADHD - neurophysiological correlates

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Frustration intolerance in ADHD - neurophysiological correlates

Irritable adolescents show lower thresholds for anger when they do not receive an expected reward.12 Irritable adolescents show reduced selective attention and response inhibition compared to normally developed peers.3

Several neurophysiological correlates have been reported for frustration intolerance (reduced frustration thresholds, e.g. when an expected reward is not received):4

  • Amygdala less activated256
  • Striatum less activated25
  • anterior and posterior cingulum less activated25
  • middle frontal gyrus less activated25
  • anterior cingulum increased activated6
  • middle frontal gyrus increased activation6
  • lateral PFC increased activated
    • for children aged 3 to 5 years7
  • greater N2 amplitude in the EEG and reduced no-go accuracy
    • for children aged 4-7 years8

  1. Meyers E, DeSerisy M, Roy AK (2017): Disruptive Mood Dysregulation Disorder (DMDD): An RDoC perspective. J Affect Disord. 2017 Jul;216:117-122. doi: 10.1016/j.jad.2016.08.007. PMID: 27554606; PMCID: PMC5305694. REVIEW

  2. Deveney CM, Connolly ME, Haring CT, Bones BL, Reynolds RC, Kim P, Pine DS, Leibenluft E (2013): Neural mechanisms of frustration in chronically irritable children. Am J Psychiatry. 2013 Oct;170(10):1186-94. doi: 10.1176/appi.ajp.2013.12070917. PMID: 23732841; PMCID: PMC3938281.

  3. Tseng WL, Deveney CM, Stoddard J, Kircanski K, Frackman AE, Yi JY, Hsu D, Moroney E, Machlin L, Donahue L, Roule A, Perhamus G, Reynolds RC, Roberson-Nay R, Hettema JM, Towbin KE, Stringaris A, Pine DS, Brotman MA, Leibenluft E (2019): Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths. Am J Psychiatry. 2019 Jan 1;176(1):67-76. doi: 10.1176/appi.ajp.2018.18040491. PMID: 30336704; PMCID: PMC6408218.

  4. Pacheco J, Garvey MA, Sarampote CS, Cohen ED, Murphy ER, Friedman-Hill SR (2022): Annual Research Review: The contributions of the RDoC research framework on understanding the neurodevelopmental origins, progression and treatment of mental illnesses. J Child Psychol Psychiatry. 2022 Apr;63(4):360-376. doi: 10.1111/jcpp.13543. Erratum in: J Child Psychol Psychiatry. 2022 Nov;63(11):1449. PMID: 34979592; PMCID: PMC8940667. REVIEW

  5. Perlman SB, Jones BM, Wakschlag LS, Axelson D, Birmaher B, Phillips ML (2015): Neural substrates of child irritability in typically developing and psychiatric populations. Dev Cogn Neurosci. 2015 Aug;14:71-80. doi: 10.1016/j.dcn.2015.07.003. PMID: 26218424; PMCID: PMC4536125.

  6. Rich BA, Carver FW, Holroyd T, Rosen HR, Mendoza JK, Cornwell BR, Fox NA, Pine DS, Coppola R, Leibenluft E (2011): Different neural pathways to negative affect in youth with pediatric bipolar disorder and severe mood dysregulation. J Psychiatr Res. 2011 Oct;45(10):1283-94. doi: 10.1016/j.jpsychires.2011.04.006. PMID: 21561628; PMCID: PMC3158808.

  7. Perlman SB, Luna B, Hein TC, Huppert TJ (2014): fNIRS evidence of prefrontal regulation of frustration in early childhood. Neuroimage. 2014 Jan 15;85 Pt 1(0 1):326-34. doi: 10.1016/j.neuroimage.2013.04.057. PMID: 23624495; PMCID: PMC3796135.

  8. Deveney CM, Briggs-Gowan MJ, Pagliaccio D, Estabrook CR, Zobel E, Burns JL, Norton ES, Pine DS, Brotman MA, Leibenluft E, Wakschlag LS (2019): Temporally sensitive neural measures of inhibition in preschool children across a spectrum of irritability. Dev Psychobiol. 2019 Mar;61(2):216-227. doi: 10.1002/dev.21792. PMID: 30328111; PMCID: PMC7147937.

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