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BDNF

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BDNF

BDNF is not a hormone, but a protein and neurotrophin. It acts as a growth factor (neurotrophic factor) in the brain. Learning requires neurotrophic factors.
Stress decreases BDNF in the hippocampus.
In ADHD, BDNF is decreased in the hippocampus, striatum, and PFC, contributing to learning problems as well as developmental problems.
Treatment with stimulants restores normal levels of BDNF and other neurotrophic factors, so that the ability to learn (not only of school or lecture material, but also in terms of meaningful changes in one’s own behavior as a result of an experience) is improved again. Endurance exercise also increases BDNF. Taurine increases BDNF in the striatum.

1. Control areas of BDNF

1.1. Behavioral functions

BDNF, in cooperation with serotonin, controls many behavioral functions.

BDNF influenced:1

  • Brain development
  • Activity-dependent synaptic plasticity2
  • The long-term potentiation (LTP) underlying learning and memory3
    • A deactivation of the BDNF gene or the BDNF receptor in mice
      • Restricts their learning behavior4 where the required learning time for spatial learning was doubled5
      • Impairs long-term potentiation, which is essential for long-term memory4
      • Prevents the improvement of learning through endurance training6
      • These effects can be remedied by external supply of BDNF7
    • GABA inhibits long-term potentiation8
  • Processes of neuronal plasticity
    • Direct
      • Cellular processes of neuronal plasticity
    • Indirect
      • Influence on other plasticity modifying processes
    • Short term
      • Potentiation of synaptic excitatory transmission by the depolarization of postsynaptic neurons
      • Facilitates the release of presynaptic neurotransmitters
    • Long-term
      • Persistent alteration of cell excitability and synaptic plasticity7

BDNF promotes hippocampal function, particularly the survival of nascent granule cells throughout adult life.9 BDNF modulates hippocampal plasticity and hippocampus-dependent memory.10

The transcription factor Cyclic AMP response element-binding protein (CREB1) is an important regulator of BDNF-induced gene expression. BDNF stimulates phosphorylation and activation of CREB in neurons.11

BDNF influences glutamate metabolism in the brain. In about 30% of neurons, glutamatergic synaptic transmission is increased by 100 ng / ml each12

  • BDNF by 143
  • Neurotrophin-4/5 by 170

cAMP rapidly increases neurotrophin-3 (= BNDF-/NT-3 = tropomyosin receptor kinase B (TrkB) = tyrosine receptor kinase B) and causes BDNF-dependent long-term potentiation in the hippocampus.13

1.2. Disturbance patterns

BDNF is involved in various disturbance patterns, e.g..

  • Depression14
    • BDNF decreases in the hippocampus
    • BDNF increased in the nucleus accumbens
  • ADHD
    • BDNF decreased in the hippocampus, PFC, and striatum
  • Schizophrenia
  • Obsessive Compulsive Disorder
  • Alzheimer14
    • BDNF decreased in parietal cortex,15 hippocampus and temporal cortex16 and entorhinal cortex17
    • NGF (nerve growth factor) was higher in dentate gyrus17
    • NT-3 was decreased in motor cortex17
  • Dementia
  • Huntington’s chorea
  • Eating disorders
    • Anorexia nervosa
    • Bulimia nervosa
  • Rett syndrome
  • Epilepsy

2. BDNF receptors

BDNF receptors are predominantly located in memory-relevant brain regions such as the PFC and hippocampus.2

2.1. TrkB receptor (TrkB)

The TrkB receptor has a high affinity for BDNF.2

2.2. Truncated TrkB receptor (TrkB-T)

2.3. P75 receptor

The p75 receptor has low affinity for BDNF.2

3. BDNF change

3.1. Stress and BDNF

3.1.1. Stress reduces BDNF in the hippocampus

Stress decreases BDNF1 and BDNF expression in the hippocampus of humans and rats. Chronic administration of antidepressants prevents this.18

BDNF was significantly reduced by singular19 such as repeated immobilization in the hippocampus and dentate gyrus, but not neurotrophin-4 or tyrosine receptor kinases (trkB or C).
In contrast, NT-3 was increased in hippocampus as well as dentate gyrus, but only during repeated immobilization (chronic stress), which was probably primarily mediated by corticosterone.
The reduction in BDNF occurred (only in the dentate gyrus) even in the absence of a corticosterone response (in rats that had had their adrenal cortex removed and thus could not secrete corticosterone).20

The decrease of BDNF by stress in the hippocampus and the increase of BDFN by stress in the paraventricular hypothalamus might decrease with age, whereas the changes of NGF (nerve growth factor) and neurotrophin-3 (NT-3) do not seem to change with age.21

One study found that BDNF was decreased by chronic glucocorticoid administration in the PFC but not in the dorsal hippocampus.22

3.1.2. Chronic stress increases BDNF in the nucleus accumbens

Chronic stress increases BDNF expression in the nucleus accumbens, which in turn correlates with depression-like behaviors, such as early passivity23 or social phobia,24 but only in stress-prone, not stress-resistant, rats.25

In people with depression, BDNF is also elevated in the nucleus accumbens.25

Stress also has significant effects on BDNF in the amygdala and PFC.9

Blocking ocular activity dramatically reduces BDNF in the visual cortex of the affected eye.14

3.1.3. Chronic / Acute Stress and Gender

In female rats, chronic stress decreased BDNF in prelimbic areas of the PFC, whereas acute stress increased BDNF in the dentate gyrus. In males, levels remained unchanged in both cases.26

3.1.4. DAT deficiency

Rodents that do not form dopamine transporters show massive alterations of BDNF in PFC and striatum:

  • In PFC
    • Decreased BDNF gene expression27
    • Total BDNF and BDNF exon IV mRNA levels reduced28
    • MRNA levels of BDNF exon VI unchanged28
    • Decreased mBDNF levels and decreased trkB activation28
    • Decreased activation of αCaMKII in the PFC28
  • In the dorsolateral striatum
    • MBDNF level in the homogenate increased28
    • MBDNF level in the cytosol increased28
    • MBDNF levels in the postsynaptic density reduced.28
    • TrkB expression in the dorsolateral striatum postsynaptically reduced28
      • TrkB is a high-affinity BNDNF receptor

3.2. Other changes from BDNF

BDNF is increased by1

  • Learning processes
  • Enriched Environment / complex environments29
    • Varied, stimulating environments increase BDNF in rats
  • Antidepressants
  • Physical activity
    • Endurance exercise significantly increases BDNF levels in the hippocampus and cerebral cortex.303132
    • Chronic estrogen deficiency of 7 weeks (but not acute estrogen deficiency of 3 weeks) reduces the increase in BDNF by endurance exercise in mice.33
  • Dietary restriction increases BDNF in the dentate gyrus34
  • Light and the circadian daylight rhythm alter BDNF and neurotrophin-3
    • In darkness, BDNF is high in the hippocampus (minimum 3.5 in light, maximum 17 in darkness)3536 in the cerebellum 37 and in the nucleus suprachiasmaticus (SCN). In the SCN, BDNF levels were highest in darkness and dawn. In constant darkness, BDNF rhythm was evident in the SCN but not in the hippocampus.38
    • Light increases, darkness decreases BDNF in the visual cortex,39 the retina and superior colliculi37 as well as in the cerebral cortex. At least in the cerebral cortex, this rhythm is modulated by norepinephrine.40
  • Sensory stimulation of tactile hair increases BDNF in the primary sensory cortex (barrel cortex).4142
  • Taurine significantly increased BDNF levels in the striatum in both SHR and WKY rats (whether low or high dose).43

4. Gene variants of BDNF

BDNF Val/Met correlated in humans, compared with BDNF Val/Val, with

  • A poorer episodic memory
  • Abnormal hippocampal activation on fMRI
  • Less N-acetyl-aspartate (NAA) in the hippocampus.10

5. BDNF reduced in ADHD

In ADHD, BDNF is decreased.30 In contrast, a study found no altered blood serum levels of BDNF, NT-3, NGF, or FGF-2 (fibroblast growth factor-2) in ADHD.44

Learning problems are typical in ADHD. Decreased BDNF in the hippocampus causes learning problems. In contrast, during chronic stress, BDNF appears to be increased in the nucleus accumbens of stress-sensitive rats (see above).

Studies on the effect of MPH on BDNF

BDNF appears to be decreased in the morning and evening in ADHD-HI and ADHD-C, and only in the evening in ADHD-I. MPH probably does not alter BDNF in ADHD-HI and ADHD-C, whereas MPH decreases BDNF in ADHD-I.45 An increase or decrease of BDNF by MPH could be age-dependent.4647

MPH increased BDNF in the dorsal striatum only in male rats as well as in the nucleus accumbens in a sex-independent manner.4849
In the PFC, MPH decreased BDNF, whereas atomoxetine increased it.49 One study found that rats that received MPH as young animals had higher BDNF levels in the PFC as they aged.50
Another study found that MPH caused a significant 42% decrease BDNF in the striatum of female rats and a significant 50.4% increase BDNF in the striatum of male rats. BDNF in the nucleus accumbens was unchanged here.51

In the dentate gyrus, only MPH, but not atomoxetine, appears to increase synaptic plasticity in rats, and a very high dose of 10 mg/kg body weight was used here. This is 5 to 15 times a usual drug dose.52

One study found no relevant effect of MPH on BDNF receptor expression in rats.53 Another study found that chronic MPH administration (1 to 3 mg/kg) increased BDNF mRNA expression in muscleblind-like 2 (Mbnl2) knockout mice.54 Another study found increased BDNF expression in the ventral tegmentum of adult rats after combined MPH/fluoxetine administration in youth.55

In conclusion, genetic circumstances, timing of MPH administration, age, sex, and brain region seem to matter for the effect MPH triggers on BDNF.

Blood serum levels of VEGF (vascular endothelial growth factor) were significantly decreased and those of GDNF (glial-derived neurotrophic factor) significantly increased in ADHD in one study. However, their blood levels did not correlate with the symptom severity of ADHD.44 Another study found no altered blood serum levels of VEGF in children with ADHD.56

In rats, MPH showed a significant increase in GDNF in the striatum and nucleus accumbens in a sex-independent manner.48

6. Measurement of BDNF and other neurotrophins

BDNF can freely cross the blood-brain barrier.575859 BDNF blood serum level is reported to correlate with hippocampal size.60


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  60. IMD-Labor: BDNF – ein Serum-Marker bei Depression und Burnout