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Norbinaltorphimine for ADHD

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Norbinaltorphimine for ADHD

Norbinaltorphimine is an opioid antagonist that has so far only been used in scientific research. Norbinaltorphimine is one of the few available highly selective kappa-opioid antagonists with a long-lasting effect.1
It is a non-stimulant.

A preclinical study in nicotine-exposed mice indicated a possible helpful effect of norbinaltorphimine in ADHD.2

Norbinaltorphimine increased dopamine and noradrenaline in the PFC in a similar way to methylphenidate, but with a significantly longer effect. At the same time, dopamine was not increased in the nucleus accumbens, which indicates a low risk of addiction.3

Diese Seite wurde am 17.04.2024 zuletzt aktualisiert.