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Norbinaltorphimine for ADHD


Norbinaltorphimine for ADHD

Norbinaltorphimine is an opioid antagonist that has so far only been used in scientific research. Norbinaltorphimine is one of the few available highly selective kappa-opioid antagonists with a long-lasting effect.1
It is a non-stimulant.

A preclinical study in nicotine-exposed mice indicated a possible helpful effect of norbinaltorphimine in ADHD.2

Norbinaltorphimine increased dopamine and noradrenaline in the PFC in a similar way to methylphenidate, but with a significantly longer effect. At the same time, dopamine was not increased in the nucleus accumbens, which indicates a low risk of addiction.3

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