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Dasotraline for ADHD

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Dasotraline for ADHD

Dasotraline is a dopamine and norepinephrine reuptake inhibitor that is currently being tested for use in ADHD.12

In a placebo-controlled double-blind study, a single daily dose of 8 mg dasotraline (but not 4 mg dasotraline) showed significant improvement in ADHD-HI Rating Scale (ADHD-HI) symptoms and CGI-S scores at 4 weeks compared with placebo.3
Side effects were mainly:

  • Sleep problems
  • Dry mouth
  • Loss of appetite
  • Nausea

At 4 mg, a good 10% of subjects terminated the study prematurely, at 8 mg just under 28%. This appears to be quite high.

The high insomnia could result from the long half-life of 47 hours, which, on the other hand, would allow a daily single dose leading to a constant plasma level after 10 days of intake.45

On the other hand, insomnia was not a predictor of dropout from study participation.