Trazodone for ADHD

Trazodone is antidepressant (SARI) that is sometimes helpful as a sleep aid in ADHD.
More on this at Krause.¹

• Phenylpiperazine
• Blockade of 5HT2A receptors leads to dopamine elevation in the striatum via glutamate reduction and enhances serotonergic neurotransmission via 5-HT1A receptors
• Low-dose (up to 50 mg): 5HT2A receptor antagonist
• Higher doses are also serotonergic and antihistaminergic. Low doses (up to 50 mg) are not serotonergic.
• Sleep-inducing in ADHD when low-dosed (25 to 100 mg)
• Half-life 5 to 9 hours
• No impairment of sexual functions
• No increase in body weight
• Strongly inhibits α1-receptors
• Weakly inhibits α2- and H1-receptors
• Attenuating effect on tremor
• Not contraindicated in glaucoma and prostate disorders
• No extrapyramidal effect (no motor restlessness)
• No potentiation of adrenergic transmission
• No anticholinergic activity, therefore does not have the typical side effects of tricyclic antidepressants
• Cross-effects:
  • Should not be combined with MAO inhibitors or (especially if high-dose) with serotonergic medications