Trazodone for ADHD
Trazodone is antidepressant (SARI) that is sometimes helpful as a sleep aid in ADHD.
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- Blockade of 5HT2A receptors leads to dopamine elevation in the striatum via glutamate reduction and enhances serotonergic neurotransmission via 5-HT1A receptors
- Low-dose (up to 50 mg): 5HT2A receptor antagonist
- Higher doses are also serotonergic and antihistaminergic. Low doses (up to 50 mg) are not serotonergic.
- Sleep-inducing in ADHD when low-dosed (25 to 100 mg)
- Half-life 5 to 9 hours
- No impairment of sexual functions
- No increase in body weight
- Strongly inhibits α1-receptors
- Weakly inhibits α2- and H1-receptors
- Attenuating effect on tremor
- Not contraindicated in glaucoma and prostate disorders
- No extrapyramidal effect (no motor restlessness)
- No potentiation of adrenergic transmission
- No anticholinergic activity, therefore does not have the typical side effects of tricyclic antidepressants
- Should not be combined with MAO inhibitors or (especially if high-dose) with serotonergic medications
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