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Trazodone for ADHD


Trazodone for ADHD

Trazodone is antidepressant (SARI) that is sometimes helpful as a sleep aid in ADHD.
More on this at Krause.1

  • Phenylpiperazine
  • Blockade of 5HT2A receptors leads to dopamine elevation in the striatum via glutamate reduction and enhances serotonergic neurotransmission via 5-HT1A receptors
  • Low-dose (up to 50 mg): 5HT2A receptor antagonist
  • Higher doses are also serotonergic and antihistaminergic. Low doses (up to 50 mg) are not serotonergic.
  • Sleep-inducing in ADHD when low-dosed (25 to 100 mg)
  • Half-life 5 to 9 hours
  • No impairment of sexual functions
  • No increase in body weight
  • Strongly inhibits α1-receptors
  • Weakly inhibits α2- and H1-receptors
  • Attenuating effect on tremor
  • Not contraindicated in glaucoma and prostate disorders
  • No extrapyramidal effect (no motor restlessness)
  • No potentiation of adrenergic transmission
  • No anticholinergic activity, therefore does not have the typical side effects of tricyclic antidepressants
  • Cross-effects:
    • Should not be combined with MAO inhibitors or (especially if high-dose) with serotonergic medications
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