Dear readers of, please forgive the disruption. needs about $36850 in 2023. In 2022 we received donations from third parties of about $ 13870. Unfortunately, 99.8% of our readers do not donate. If everyone who reads this request makes a small contribution, our fundraising campaign for 2023 would be over after a few days. This donation request is displayed 18,000 times a week, but only 40 people donate. If you find useful, please take a minute and support with your donation. Thank you!

Since 01.06.2021 is supported by the non-profit ADxS e.V..

$16307 of $36850 - as of 2023-08-31
Header Image
Tipepidine for ADHD


Tipepidine for ADHD

Tipepidine (3-[di-2-thienylmethylene]-1-methylpiperidine) is a synthetic, non-opioid cough blocker (antitussive). Tipepidine increases dopamine levels in the nucleus accumbens via inhibition of GIRK channels, but without increasing motor activity or producing methamphetamine-like behavioral sensitization.
It has been used in Japan since 1959 and could be an interesting alternative to MPH and AMP due to its lack of stimulant properties.1

Tipepidine alone shows significant improvements in ADHD symptomatology.2
A placebo-based double-blind study found a beneficial effect of tipepidine given in addition to MPH.3

Tipepidine showed some promising results in improving ADHD symptoms in several Phase 2 clinical trials.4 Further studies have not yet been initiated.5

Diese Seite wurde am 13.03.2023 zuletzt aktualisiert.