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Levophacetoperane for ADHD

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Levophacetoperane for ADHD

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Levophacetoperane1

Other names: NLS-3 or (R, R)-enantiomer of phacetoperane
Brand name: Lidepran® (8228 R.P.)

Levophacetoperane is the reverse ester of methylphenidate.
It was marketed in Canada and Europe in the late 1950s for the treatment of ADHD, obesity and depression.

(Levo-)phacetoperane differs from other stimulants in its effect on the catecholamine system and showed a favorable risk-benefit ratio.
It has been in extensive clinical use in almost a thousand children and adolescents. It was found to have fewer side effects than comparable stimulant treatments in large dose ranges.

  1. Konofal E, Lecendreux M, Bizot JC, Lormier AT, Figadere B (2023): NLS-3 (Levophacetoperane or (R,R) Phacetoperane): A Reverse Ester of Methylphenidate: A Literature Review. Curr Med Chem. 2023 Jan 20. doi: 10.2174/0929867330666230120161837. PMID: 36683369. REVIEW ↥

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