Quinpirole for ADHD

Whether this amplification of hypermotor activity also occurs in ADHD-HI/ADHD-C sufferers is open to question. Hyperactivity is located in the striatum. However, symptoms are caused by a non-optimal neurotransmitter level, in this case hyperactivity due to dopamine deficiency as well as dopamine excess.
If quinpirole raises dopamine levels in the striatum, it is plausible that hyperactivity symptoms will occur in unaffected individuals.
In ADHD-HI and ADHD-C, however, there is a dopamine deficit in the striatum. It should follow from this that quinpirole eliminates this deficit and thus reduces hyperactivity at the same time.

In ADHD, a dopamine deficiency in the PFC is further hypothesized. A further reduction in dopamine levels would therefore be detrimental.
However, in ADHD, it is primarily the medial and right PFC that is affected.
How detrimental quinpirole’s reduced dopamine levels in the left PFC are in ADHD is an open question.