Centanafadine for ADHD
Centanafadine is a
- Norepinephrine reuptake inhibitor
- Dopamine reuptake inhibitor
- Serotonin reuptake inhibitors.
Two randomized, double-blind, placebo-controlled, parallel-group, phase 3 studies were conducted in adults with ADHD with 200 mg/d or 400 mg/d of centanafadine sustained-release tablets.1
At day 42, both studies showed improvements in AISRS total score versus placebo with effect sizes of -0.28 for 200 mg/d and -0.24 for 400 mg/d in study 1 and -0.37 for 200 mg/d and -0.40 for 400 mg/d in study 2
Centanafadine was well tolerated, and the overall rate of adverse events was low but dose-dependent.
Adler, Adams, Madera-McDonough, Kohegyi, Hobart, Chang D, Angelicola, McQuade, Liebowitz (2022): Efficacy, Safety, and Tolerability of Centanafadine Sustained-Release Tablets in Adults With Attention-Deficit/Hyperactivity Disorder: Results of 2 Phase 3, Randomized, Double-blind, Multicenter, Placebo-Controlled Trials. J Clin Psychopharmacol. 2022 Jun 2. doi: 10.1097/JCP.0000000000001575. PMID: 35652746. ↥