Centanafadine for ADHD

Centanafadine is a

• Norepinephrine reuptake inhibitor
• Dopamine reuptake inhibitor
• Serotonin reuptake inhibitors.

Two randomized, double-blind, placebo-controlled, parallel-group, phase 3 studies were conducted in adults with ADHD with 200 mg/d or 400 mg/d of centanafadine sustained-release tablets.¹
At day 42, both studies showed improvements in AISRS total score versus placebo with effect sizes of -0.28 for 200 mg/d and -0.24 for 400 mg/d in study 1 and -0.37 for 200 mg/d and -0.40 for 400 mg/d in study 2

Centanafadine was well tolerated, and the overall rate of adverse events was low but dose-dependent.