L-Carnosine for ADHD
One study found that in ADHD-C sufferers, L-carnosine support of MPH treatment positively influenced symptoms compared to MPH + placebo.1 Meanwhile, L-carnosine does not appear to have a direct effect on GABA.2
L-carnosine has been reported to increase cortisol levels,3 which could address cortisol deficiency as a stress response in ADHD-HI sufferers (ADHD-C/with hyperactivity).
From this perspective, treatment of ADHD-I subtype (as well as probably SCT) using L-carnosine would be viewed with caution.
There are no studies on the use of L-carnosine in ADHD.
Ghaja, Aghajan-Nashtaei, Afarideh, Mohammadi, Akhondzadeh (2018): l-Carnosine as Adjunctive Therapy in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Child Adolesc Psychopharmacol. 2018 Jun;28(5):331-338. doi: 10.1089/cap.2017.0157. ↥
Trombley, Horning, Blakemore (1999): Interactions between Carnosine and Zinc and Copper: Implications for Neuromodulation and Neuroprotection, Biochemistry (Moscow), Vol. 65, No. 7, 2000, pp. 807-816. Translated from Biokhimiya, Vol. 65, No. 7, 2000, pp. 949-960; Seite 810 ↥