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L-Carnosine for ADHD

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L-Carnosine for ADHD

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One study found that in ADHD-C sufferers, L-carnosine support of MPH treatment positively influenced symptoms compared to MPH + placebo.1 Meanwhile, L-carnosine does not seem to have a direct influence on GABA.2

L-carnosine has been reported to increase cortisol levels,3 which could address cortisol deficiency as a stress response in ADHD-HI sufferers (ADHD-C/with hyperactivity).
From this perspective, treatment of ADHD-I subtype (as well as probably SCT) using L-carnosine would be viewed with caution.

There are no studies on the use of L-carnosine in ADHD.

  1. Ghaja, Aghajan-Nashtaei, Afarideh, Mohammadi, Akhondzadeh (2018): l-Carnosine as Adjunctive Therapy in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Child Adolesc Psychopharmacol. 2018 Jun;28(5):331-338. doi: 10.1089/cap.2017.0157. ↥

  2. Trombley, Horning, Blakemore (1999): Interactions between Carnosine and Zinc and Copper: Implications for Neuromodulation and Neuroprotection, Biochemistry (Moscow), Vol. 65, No. 7, 2000, pp. 807-816. Translated from Biokhimiya, Vol. 65, No. 7, 2000, pp. 949-960; Seite 810 ↥

  3. https://de.wikipedia.org/wiki/L-Carnosin ↥

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