L-carnosine for ADHD
One study found that in people with ADHD-C, support for MPH treatment with L-carnosine had a positive effect on symptoms compared to MPH + placebo.1 However, L-carnosine does not appear to have a direct influence on GABA.2
L-carnosine has been reported to increase cortisol levels,3 which could remedy the cortisol deficiency as a stress response in persons with ADHD-HI (ADHD-C/with hyperactivity).
From this perspective, treatment of ADHD-I subtype (and probably also SCT) with L-carnosine should be viewed with caution.
There is no research on the use of L-carnosine for ADHD.
Ghaja, Aghajan-Nashtaei, Afarideh, Mohammadi, Akhondzadeh (2018): l-Carnosine as Adjunctive Therapy in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Child Adolesc Psychopharmacol. 2018 Jun;28(5):331-338. doi: 10.1089/cap.2017.0157. ↥
Trombley, Horning, Blakemore (1999): Interactions between Carnosine and Zinc and Copper: Implications for Neuromodulation and Neuroprotection, Biochemistry (Moscow), Vol. 65, No. 7, 2000, pp. 807-816. Translated from Biokhimiya, Vol. 65, No. 7, 2000, pp. 949-960; Seite 810 ↥