Alpha-2 agonists for ADHD

Alpha-2 agonists bind to alpha-2 adrenoreceptors in the PFC¹
They have an effect on

• Inattention
• Hyperactivity
• Impulsiveness
• Tics.3

Alpha-2-agnists are

• Guanfacine
• Clonidine

Both are available as immediate-release or sustained-release preparations
Guanfacine ER and clonidine ER are approved by the FDA for the treatment of ADHD.

The IR formulations of guanfacine and clonidine are sometimes used off-label, especially in patients who cannot swallow tablets or when insurance does not cover the ER form. IR alpha agonists must be taken 3 to 4 times daily, and their use may be limited by daytime sedation.

Alpha agonists may be beneficial in the treatment of children with ADHD and comorbid tic disorders or oppositional behavior.
More on this in the articles

• Guanfacine for ADHD
• Clonidine for ADHD