Magnesium L-threonate for ADHD
Magnesium L-threonate is a compound of magnesium and L-threonic acid. Magnesium L-threonate is a degradation product of vitamin C.
Magnesium L-threonate is said to be one of the first drug candidates for ADHD that works by modulating the glutamatergic system1
A very small study claims to have found benefits of complementary administration of magnesium L-threonate (L-threonic acid magnesium salt).23 A slightly larger study (N = 105) found improvements in memory with a magnesium L-threonate formula4
Phase III studies on magnesium L-threonate are to be conducted.5
NRCT-101SR and NRCT-101XR are medicines containing magnesium L-threonate.6
In preclinical studies, NRCT-101SR showed an increase in glutamatergic synapse density, function and plasticity in PFC and hippocampus. This may help to improve cognitive function and mood regulation.1
NRCT-101SR is currently being investigated in Phase IIb and Phase III clinical trials for the treatment of ADHD in adults and children.78
Ferahkaya H, Bilgic A (2025): Potential treatments for attention-deficit/hyperactivity disorder: a focus on Phase III trials. Expert Opin Pharmacother. 2025 Oct-Oct;26(14-15):1539-1547. doi: 10.1080/14656566.2025.2566257. PMID: 40986064. REVIEW ↥ ↥
Surman, Vaudreuil, Boland, Rhodewalt, DiSalvo, Biederman (2020): L-Threonic Acid Magnesium Salt Supplementation in ADHD: An Open-Label Pilot Study. J Diet Suppl. 2020 Mar 12:1-13. doi: 10.1080/19390211.2020.1731044. PMID: 32162987. n = 15 ↥
Zhang C, Hu Q, Li S, Dai F, Qian W, Hewlings S, Yan T, Wang Y (2022): A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults. Nutrients. 2022 Dec 8;14(24):5235. doi: 10.3390/nu14245235. PMID: 36558392; PMCID: PMC9786204. ↥
Childress A (2024): Recent advances in pharmacological management of attention-deficit/hyperactivity disorder: moving beyond stimulants. Expert Opin Pharmacother. 2024 May;25(7):853-866. doi: 10.1080/14656566.2024.2358987. PMID: 38771653. REVIEW ↥
https://delta.larvol.com/Products/?ProductId=9238d4ac-a604-48b5-b160-5783aad87897 ↥
https://ctv.veeva.com/study/a-phase-2-randomized-double-blind-parallel-adaptive-design-clinical-trial-to-evaluate-the-safety ↥