Mirtazapine for ADHD

Brand name: Remergil

Dopaminergic, adrenergic and noradrenergic, but not serotonergic antidepressant.

Increases the release of dopamine in the PFC and noradrenergic transmission in cortical-limbic areas.¹

The serotonin level is only insignificantly affected.¹

After 21 days of mirtazapine treatment, rats showed desensitization of presynaptic a2 heteroreceptors at the 5-HT nerve terminal in the hippocampus. This resulted in increased tonic activation of postsynaptic 5-HT1A receptors.² This increased tonic activation of inhibitory 5-HT1A receptors could explain the increased CRH release in the HPA axis, which was still acutely reduced before the start of treatment.³