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Mirtazapine for ADHD


Mirtazapine for ADHD

Brand name: Remergil

Dopaminergic, adrenergic, and noradrenergic but not serotonergic antidepressant.

Increases the release of dopamine in the PFC and noradrenergic transmission in cortical-limbic areas.1

Serotonin levels are only marginally affected.1

After 21 days of mirtazapine treatment, rats showed desensitization of presynaptic a2 heteroreceptors at the 5-HT nerve terminal in the hippocampus. This caused increased tonic activation of postsynaptic 5-HT1A receptors.2 This increased tonic activation of inhibitory 5-HT1A receptors could explain the increased CRH release in the HPA axis, which was acutely reduced before treatment initiation.3

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